ROTARIX

Rotarix is an oral vaccine developed by GSK that provides protection against rotavirus, a highly contagious virus responsible for severe diarrhea, vomiting, and dehydration in infants and young children. Rotavirus is a leading cause of gastroenteritis-related hospitalizations in this age group, making vaccination essential.

How It Works

Rotarix contains a live, attenuated (weakened) human rotavirus strain, specifically designed to protect against the most common rotavirus type. It is a monovalent vaccine, meaning it targets a single strain of rotavirus (the G1P[8] strain), which is responsible for the majority of rotavirus infections globally. By using a human rotavirus strain, Rotarix closely mimics natural infection, providing robust and effective immunity.

Administration

• Dosage: Rotarix is typically administered as a two-dose series.
• Schedule: The first dose is given at 6 weeks of age, followed by the second dose at least 4 weeks later, usually before the infant reaches 24 weeks of age.
• Administration Method: Given orally as drops directly into the infant’s mouth.

Side Effects

Common side effects may include:

• Mild diarrhea
• Irritability
• Cough or runny nose
• Mild fever

Severe reactions are rare.

Pregnancy and Lactation

• Pregnancy: Not applicable, as Rotarix is intended for infants.
• Lactation: Safe for breastfeeding mothers to administer to their infants.

Minimum Age Group

• Minimum Age: Approved for use in infants starting at 6 weeks old.

Contraindications

• Allergic Reactions: Not recommended for infants with severe allergies to any component of the vaccine.
• Severe Combined Immunodeficiency (SCID): Should not be given to infants with SCID.
• History of Intussusception: Not recommended for infants with a history of intussusception, a condition in which part of the intestine slides into an adjacent part of the intestine.

Rotarix is a crucial vaccine in preventing rotavirus infections, significantly reducing the incidence of severe gastroenteritis and associated hospitalizations in infants and young children. As a monovalent vaccine, it effectively targets the predominant rotavirus strain, making it a key component of routine childhood immunization programs. Always consult healthcare providers for detailed vaccination schedules and personalized advice.