SHINGRIX

Shingrix is a vaccine designed to protect against shingles (herpes zoster), a painful rash caused by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Shingles can lead to severe nerve pain, known as postherpetic neuralgia (PHN), and other complications, particularly in older adults. Shingrix is highly effective in preventing shingles and its associated complications.

How It Works

Shingrix is a recombinant, adjuvanted vaccine. It contains a non-live antigen, glycoprotein E, from the varicella-zoster virus, combined with an adjuvant system called AS01B, which enhances the body’s immune response. When administered, Shingrix stimulates the immune system to produce antibodies and activate T-cells against the virus, providing strong and long-lasting protection against shingles.

Administration

• Dosage: Shingrix is administered as a two-dose series.
• Schedule: The first dose is followed by a second dose 2 to 6 months later.
• Administration Method: Given as an intramuscular injection, usually in the upper arm (deltoid muscle).

Side Effects

Common side effects may include:

• Pain, redness, or swelling at the injection site
• Muscle pain
• Fatigue
• Headache
• Chills
• Fever
• Nausea

These side effects are typically mild to moderate and usually resolve on their own.

Pregnancy and Lactation

• Pregnancy: Shingrix is not typically recommended during pregnancy. Women who are pregnant should discuss the timing of vaccination with their healthcare provider.
• Lactation: The vaccine may be administered to breastfeeding mothers if the benefits outweigh the risks, but consultation with a healthcare provider is recommended.

Age Group

• Minimum Age: Approved for use in individuals 50 years and older.
• Upper Age Limit: There is no upper age limit for receiving Shingrix.

Contraindications

• Allergic Reactions: Not recommended for individuals with severe allergies to any component of the vaccine or to a previous dose of Shingrix.
• Severe Illness: Vaccination should be postponed in cases of acute, severe febrile illness.

Nature of Antigen

• Nature of Antigen: Shingrix contains a recombinant glycoprotein E antigen from the varicella-zoster virus, combined with an adjuvant system (AS01B) to boost the immune response.

Vaccine Type

• Type: Shingrix is a recombinant, non-live vaccine, specifically designed to protect against shingles.

Origin and Manufacturer

• Origin: Shingrix is an imported vaccine.
• Manufacturer: The vaccine is produced by GlaxoSmithKline (GSK), a global healthcare company.
• Introduction Year: Shingrix was introduced in 2017.

Shingrix is a highly effective vaccine for preventing shingles and its complications, particularly in adults aged 50 and older. Developed and produced by GlaxoSmithKline, Shingrix provides strong and lasting protection against a virus that can cause significant pain and discomfort. Always consult healthcare providers for detailed vaccination schedules and personalized advice.